畜禽动物中长链非编码RNA的研究现状

doi:10.11843/j.issn.0366-6964.2016.05.002

摘要/Abstract

摘要：

长链非编码RNA(Long noncoding RNAs，lncRNA)是一类转录本长度超过200 nt的非编码RNA分子，它们以RNA的形式在表观遗传调控、转录调控以及转录后调控等多层面调控基因的表达。它们参与细胞增殖、分化和凋亡等多种生物学过程。近年来，lncRNA在畜禽动物中的研究越来越受到人们的重视，人们发现lncRNA在动物生长发育中扮演着很重要的角色。本文对近十五年来畜禽动物如猪、鸡、羊和牛中lncRNA的高通量筛选与鉴定、表达、在不同物种中的进化以及功能等研究现状进行综述。

Abstract:

Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs with longer in length than 200 nucleotides that function is multifaceted in epigenetic regulation，transcriptional regulation and post-transcriptional regulation.LncRNAs have important roles in many biological processes including cell proliferation，differentiation and apoptosis.In recent years，more and more attention has been paid to the research of lncRNAs in farm animals.It is found that lncRNAs play important role in the growth and development of animals.In this review，we highlight the advances on the high throughput screening，identification，expression，evolution and function of lncRNAs in important farm animal species，such as pig，chicken，sheep and cattle in the past 15 years.

中图分类号:

S813.3

戴梦红，陆启荣，程古月，李丽，刘孟轲，郝海红，王旭，袁宗辉. 畜禽动物中长链非编码RNA的研究现状[J]. 畜牧兽医学报, 2016, 47(5): 864-869.

DAI Meng-hong，LU Qi-rong，CHENG Gu-yue，LI Li，LIU Meng-ke，HAO Hai-hong，WANG Xu，YUAN Zong-hui. The Progress on Long Noncoding RNAs in Farm Animals[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(5): 864-869.

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